1j8f

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[[Image:1j8f.gif|left|200px]]
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{{Seed}}
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[[Image:1j8f.png|left|200px]]
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{{STRUCTURE_1j8f| PDB=1j8f | SCENE= }}
{{STRUCTURE_1j8f| PDB=1j8f | SCENE= }}
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'''HUMAN SIRT2 HISTONE DEACETYLASE'''
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===HUMAN SIRT2 HISTONE DEACETYLASE===
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==Overview==
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Sir2 is an NAD-dependent histone deacetylase that mediates transcriptional silencing at mating-type loci, telomeres and ribosomal gene clusters, and has a critical role in the determination of life span in yeast and Caenorhabditis elegans. The 1.7 A crystal structure of the 323 amino acid catalytic core of human SIRT2, a homolog of yeast Sir2, reveals an NAD-binding domain, which is a variant of the Rossmann fold, and a smaller domain composed of a helical module and a zinc-binding module. A conserved large groove at the interface of the two domains is the likely site of catalysis based on mutagenesis. Intersecting this large groove, there is a pocket formed by the helical module. The pocket is lined with hydrophobic residues conserved within each of the five Sir2 classes, suggesting that it is a class-specific protein-binding site.
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The line below this paragraph, {{ABSTRACT_PUBMED_11427894}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11427894 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11427894}}
==About this Structure==
==About this Structure==
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[[Category: Sirt2]]
[[Category: Sirt2]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:54:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:37:59 2008''

Revision as of 11:38, 1 July 2008

Image:1j8f.png

Template:STRUCTURE 1j8f

HUMAN SIRT2 HISTONE DEACETYLASE

Template:ABSTRACT PUBMED 11427894

About this Structure

1J8F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the histone deacetylase SIRT2., Finnin MS, Donigian JR, Pavletich NP, Nat Struct Biol. 2001 Jul;8(7):621-5. PMID:11427894

Page seeded by OCA on Tue Jul 1 14:37:59 2008

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