8ez7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8ez7 is ON HOLD until Paper Publication
+
==Structure of 1F04 Fab in complex with A/Moscow/10/1999 (H3N2) influenza virus neuraminidase==
-
 
+
<StructureSection load='8ez7' size='340' side='right'caption='[[8ez7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
Authors: Mou, Z., Lei, R., Wu, N.C., Dai, X.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8ez7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Moscow/10/1999(H3N2)) Influenza A virus (A/Moscow/10/1999(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EZ7 FirstGlance]. <br>
-
Description: Structure of 1F04 Fab in complex with A/Moscow/10/1999 (H3N2) influenza virus neuraminidase
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
[[Category: Mou, Z]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ez7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ez7 OCA], [https://pdbe.org/8ez7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ez7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ez7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ez7 ProSAT]</span></td></tr>
-
[[Category: Wu, N.C]]
+
</table>
-
[[Category: Dai, X]]
+
== Function ==
-
[[Category: Lei, R]]
+
[https://www.uniprot.org/uniprot/Q8AZ87_9INFA Q8AZ87_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Dai X]]
 +
[[Category: Lei R]]
 +
[[Category: Mou Z]]
 +
[[Category: Wu NC]]

Revision as of 11:58, 8 November 2023

Structure of 1F04 Fab in complex with A/Moscow/10/1999 (H3N2) influenza virus neuraminidase

PDB ID 8ez7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8ez7"
Personal tools