7xur
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7xur]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XUR FirstGlance]. <br> | <table><tr><td colspan='2'>[[7xur]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XUR FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.49Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xur OCA], [https://pdbe.org/7xur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xur RCSB], [https://www.ebi.ac.uk/pdbsum/7xur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xur ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xur OCA], [https://pdbe.org/7xur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xur RCSB], [https://www.ebi.ac.uk/pdbsum/7xur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xur ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SNPC4_HUMAN SNPC4_HUMAN] The disease is caused by variants affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SNPC4_HUMAN SNPC4_HUMAN] Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.<ref>PMID:12621023</ref> <ref>PMID:9418884</ref> | [https://www.uniprot.org/uniprot/SNPC4_HUMAN SNPC4_HUMAN] Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.<ref>PMID:12621023</ref> <ref>PMID:9418884</ref> | ||
Current revision
The cryo-EM structure of human mini-SNAPc in complex with hU6-1 PSE
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