1j95

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{{STRUCTURE_1j95| PDB=1j95 | SCENE= }}
{{STRUCTURE_1j95| PDB=1j95 | SCENE= }}
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'''KCSA potassium channel with TBA (tetrabutylammonium) and potassium'''
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===KCSA potassium channel with TBA (tetrabutylammonium) and potassium===
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==Overview==
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Many voltage-dependent K+ channels open when the membrane is depolarized and then rapidly close by a process called inactivation. Neurons use inactivating K+ channels to modulate their firing frequency. In Shaker-type K+ channels, the inactivation gate, which is responsible for the closing of the channel, is formed by the channel's cytoplasmic amino terminus. Here we show that the central cavity and inner pore of the K+ channel form the receptor site for both the inactivation gate and small-molecule inhibitors. We propose that inactivation occurs by a sequential reaction in which the gate binds initially to the cytoplasmic channel surface and then enters the pore as an extended peptide. This mechanism accounts for the functional properties of K+ channel inactivation and indicates that the cavity may be the site of action for certain drugs that alter cation channel function.
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The line below this paragraph, {{ABSTRACT_PUBMED_11395760}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11395760 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11395760}}
==About this Structure==
==About this Structure==
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Metal transport]]
[[Category: Metal transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:56:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:40:30 2008''

Revision as of 11:40, 1 July 2008

Image:1j95.png

Template:STRUCTURE 1j95

KCSA potassium channel with TBA (tetrabutylammonium) and potassium

Template:ABSTRACT PUBMED 11395760

About this Structure

1J95 is a Single protein structure of sequence from Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors., Zhou M, Morais-Cabral JH, Mann S, MacKinnon R, Nature. 2001 Jun 7;411(6838):657-61. PMID:11395760

Page seeded by OCA on Tue Jul 1 14:40:30 2008

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