1csl

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csl OCA], [https://pdbe.org/1csl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1csl RCSB], [https://www.ebi.ac.uk/pdbsum/1csl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1csl ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-purine base-pairs and two single nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies.

The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution.,Ippolito JA, Steitz TA J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:10656783<ref>PMID:10656783</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

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