8b9n

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Current revision (14:04, 18 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8b9n is ON HOLD until Paper Publication
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==Crystal structure of NEI domain of mouse NEIL3 trapped in covalent complex with ssDNA with abasic site==
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<StructureSection load='8b9n' size='340' side='right'caption='[[8b9n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8b9n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B9N FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DRZ:3,4-DIHYDROXY-PENTANAL-5-PHOSPHATE'>DRZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b9n OCA], [https://pdbe.org/8b9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b9n RCSB], [https://www.ebi.ac.uk/pdbsum/8b9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b9n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEIL3_MOUSE NEIL3_MOUSE] DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.<ref>PMID:20185759</ref> <ref>PMID:22065741</ref> <ref>PMID:22569481</ref> <ref>PMID:22959434</ref> <ref>PMID:23305905</ref> <ref>PMID:23313161</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Boura E]]
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[[Category: Klima M]]
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[[Category: Silhan J]]

Current revision

Crystal structure of NEI domain of mouse NEIL3 trapped in covalent complex with ssDNA with abasic site

PDB ID 8b9n

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OCA

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