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8ez1

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'''Unreleased structure'''
 
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The entry 8ez1 is ON HOLD until Paper Publication
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==Human Ornithine Aminotransferase (hOAT) co-crystallized with its inactivator 3-Amino-4-fluorocyclopentenecarboxylic Acid==
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<StructureSection load='8ez1' size='340' side='right'caption='[[8ez1]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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Authors: Butrin, A., Shen, S., Silverman, R., Liu, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ez1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EZ1 FirstGlance]. <br>
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Description: Human Ornithine Aminotransferase (hOAT) co-crystallized with its inactivator 3-Amino-4-fluorocyclopentenecarboxylic Acid
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X8B:(3E,4E)-4-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-iminocyclopent-1-ene-1-carboxylic+acid'>X8B</scene>, <scene name='pdbligand=X8H:(1R,3S,4Z)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic+acid'>X8H</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ez1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ez1 OCA], [https://pdbe.org/8ez1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ez1 RCSB], [https://www.ebi.ac.uk/pdbsum/8ez1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ez1 ProSAT]</span></td></tr>
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[[Category: Liu, D]]
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</table>
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[[Category: Shen, S]]
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== Disease ==
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[[Category: Butrin, A]]
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[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN] Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:[https://omim.org/entry/258870 258870]. HOGA is a slowly progressive blinding autosomal recessive disorder.<ref>PMID:3375240</ref> <ref>PMID:2793865</ref> <ref>PMID:1612597</ref> <ref>PMID:1737786</ref> <ref>PMID:7887415</ref> <ref>PMID:7668253</ref>
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[[Category: Silverman, R]]
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== Function ==
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[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Butrin A]]
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[[Category: Liu D]]
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[[Category: Shen S]]
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[[Category: Silverman R]]

Revision as of 12:44, 22 February 2023

Human Ornithine Aminotransferase (hOAT) co-crystallized with its inactivator 3-Amino-4-fluorocyclopentenecarboxylic Acid

PDB ID 8ez1

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OCA

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