8hkw
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal== | |
| - | + | <StructureSection load='8hkw' size='340' side='right'caption='[[8hkw]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8hkw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HKW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hkw OCA], [https://pdbe.org/8hkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hkw RCSB], [https://www.ebi.ac.uk/pdbsum/8hkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hkw ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Matsuura | + | == Disease == |
| + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Matsuura Y]] | ||
Revision as of 09:31, 21 December 2022
Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal
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