1jcc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jcc.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1jcc.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jcc| PDB=1jcc | SCENE= }}
{{STRUCTURE_1jcc| PDB=1jcc | SCENE= }}
-
'''Crystal Structure of a Novel Alanine-Zipper Trimer at 1.7 A Resolution, V13A,L16A,V20A,L23A,V27A,M30A,V34A mutations'''
+
===Crystal Structure of a Novel Alanine-Zipper Trimer at 1.7 A Resolution, V13A,L16A,V20A,L23A,V27A,M30A,V34A mutations===
-
==Overview==
+
<!--
-
Specific sequence signals at alpha-helix termini can assist protein folding by punctuating and cueing secondary structural elements in the final native conformation. Here we report the crystallization of a 56-residue alanine-containing peptide, denoted Ala-10(56), in the presence of Zn(2+). The 1.7 A crystal structure shows that Ala-10(56) forms a parallel trimeric coiled coil with three zinc ions anchoring distinct capping conformations at the amino-terminal ends of the three helices. In each polypeptide chain, the free alpha-amino nitrogen and carbonyl oxygen of the amino-terminal Ser residue coordinate to a Zn(2+) ion to form a five-membered chelate, and the syn-unidentate interaction of the Asp7 side chain with the Zn(2+) cation leads to the formation of a unique docking arrangement for helix capping. Moreover, the coordination of the zinc ion involves a neighboring trimer molecule in the crystal. Consequently, the crystal contacts are stabilized by carboxylate-Zn(2+) interactions between four Ala-10(56) trimers in the crystal lattice. The observed synergy between the protein-zinc ion recognition and the helix-packing arrangements would contribute to the conformational specificity of the Ala-10(56) trimer.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12741822}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12741822 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12741822}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
[[Category: Protein folding]]
[[Category: Protein folding]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:02:55 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:00:55 2008''

Revision as of 17:00, 1 July 2008

Image:1jcc.png

Template:STRUCTURE 1jcc

Crystal Structure of a Novel Alanine-Zipper Trimer at 1.7 A Resolution, V13A,L16A,V20A,L23A,V27A,M30A,V34A mutations

Template:ABSTRACT PUBMED 12741822

About this Structure

1JCC is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Zinc-mediated helix capping in a triple-helical protein., Liu J, Dai J, Lu M, Biochemistry. 2003 May 20;42(19):5657-64. PMID:12741822

Page seeded by OCA on Tue Jul 1 20:00:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jcc"
Personal tools