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1jch

From Proteopedia

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{{STRUCTURE_1jch| PDB=1jch | SCENE= }}
{{STRUCTURE_1jch| PDB=1jch | SCENE= }}
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'''Crystal Structure of Colicin E3 in Complex with its Immunity Protein'''
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===Crystal Structure of Colicin E3 in Complex with its Immunity Protein===
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==Overview==
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Colicins kill E. coli by a process that involves binding to a surface receptor, entering the cell, and, finally, intoxicating it. The lethal action of colicin E3 is a specific cleavage in the ribosomal decoding A site. The crystal structure of colicin E3, reported here in a binary complex with its immunity protein (IP), reveals a Y-shaped molecule with the receptor binding domain forming a 100 A long stalk and the two globular heads of the translocation domain (T) and the catalytic domain (C) comprising the two arms. Active site residues are D510, H513, E517, and R545. IP is buried between T and C. Rather than blocking the active site, IP prevents access of the active site to the ribosome.
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{{ABSTRACT_PUBMED_11741540}}
==About this Structure==
==About this Structure==
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[[Category: The rnase domain is a six-stranded antiparallel beta-sheet. the immunity protein is a four-stranded antiparallel beta sheet flanked by 3 helices on one side of the sheet]]
[[Category: The rnase domain is a six-stranded antiparallel beta-sheet. the immunity protein is a four-stranded antiparallel beta sheet flanked by 3 helices on one side of the sheet]]
[[Category: Translocation domain is a beta-jellyroll]]
[[Category: Translocation domain is a beta-jellyroll]]
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Revision as of 17:01, 1 July 2008

Image:1jch.png


PDB ID 1jch

Drag the structure with the mouse to rotate
1jch, resolution 3.02Å ()
Ligands: ,
Related: 3eip, 1e44
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Colicin E3 in Complex with its Immunity Protein

Template:ABSTRACT PUBMED 11741540

About this Structure

1JCH is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of colicin E3: implications for cell entry and ribosome inactivation., Soelaiman S, Jakes K, Wu N, Li C, Shoham M, Mol Cell. 2001 Nov;8(5):1053-62. PMID:11741540

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