8fg7

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m (Protected "8fg7" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8fg7 is ON HOLD
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==Apo mouse acidic mammalian chitinase, catalytic domain at 277 K==
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<StructureSection load='8fg7' size='340' side='right'caption='[[8fg7]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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Authors: Diaz, R.E., Asthana, P., Fraser, J.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8fg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FG7 FirstGlance]. <br>
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Description: Apo mouse acidic mammalian chitinase, catalytic domain at 277 K
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fg7 OCA], [https://pdbe.org/8fg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fg7 RCSB], [https://www.ebi.ac.uk/pdbsum/8fg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fg7 ProSAT]</span></td></tr>
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[[Category: Diaz, R.E]]
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</table>
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[[Category: Asthana, P]]
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== Function ==
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[[Category: Fraser, J.S]]
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[https://www.uniprot.org/uniprot/CHIA_MOUSE CHIA_MOUSE] Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme.<ref>PMID:11085997</ref> <ref>PMID:12133911</ref> <ref>PMID:15192232</ref> <ref>PMID:19076793</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Asthana P]]
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[[Category: Diaz RE]]
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[[Category: Fraser JS]]

Revision as of 06:05, 2 March 2023

Apo mouse acidic mammalian chitinase, catalytic domain at 277 K

PDB ID 8fg7

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