1jek

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[[Image:1jek.jpg|left|200px]]
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{{Seed}}
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[[Image:1jek.png|left|200px]]
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{{STRUCTURE_1jek| PDB=1jek | SCENE= }}
{{STRUCTURE_1jek| PDB=1jek | SCENE= }}
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'''Visna TM CORE STRUCTURE'''
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===Visna TM CORE STRUCTURE===
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==Overview==
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Structural studies of viral membrane fusion proteins suggest that a "trimer-of-hairpins" motif plays a critical role in the membrane fusion process of many enveloped viruses. In this motif, a coiled coil (formed by homotrimeric association of the N-terminal regions of the protein) is surrounded by three C-terminal regions that pack against the coiled coil in an oblique antiparallel manner. The resulting trimer-of-hairpins structure serves to bring the viral and cellular membranes together for fusion. learncoil-vmf, a computational program developed to recognize coiled coil-like regions that form the trimer-of-hairpins motif, predicts these regions in the membrane fusion protein of the Visna virus. Peptides corresponding to the computationally identified sequences were synthesized, and the soluble core of the Visna membrane fusion protein was reconstituted in solution. Its crystal structure at 1.5-A resolution demonstrates that a trimer-of-hairpins structure is formed. Remarkably, despite less than 23% sequence identity, the ectodomains in Visna and HIV-1 envelope glycoproteins show detailed structural conservation, especially within the area of a hydrophobic pocket in the central coiled coil currently being targeted for the development of new anti-HIV drugs.
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The line below this paragraph, {{ABSTRACT_PUBMED_11447278}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11447278 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11447278}}
==About this Structure==
==About this Structure==
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[[Category: Retrovirus]]
[[Category: Retrovirus]]
[[Category: Siv]]
[[Category: Siv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:07:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:07:24 2008''

Revision as of 17:07, 1 July 2008

Image:1jek.png

Template:STRUCTURE 1jek

Visna TM CORE STRUCTURE

Template:ABSTRACT PUBMED 11447278

About this Structure

1JEK is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

The trimer-of-hairpins motif in membrane fusion: Visna virus., Malashkevich VN, Singh M, Kim PS, Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8502-6. Epub 2001 Jul 10. PMID:11447278

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