1jeq

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{{STRUCTURE_1jeq| PDB=1jeq | SCENE= }}
{{STRUCTURE_1jeq| PDB=1jeq | SCENE= }}
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'''Crystal Structure of the Ku Heterodimer'''
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===Crystal Structure of the Ku Heterodimer===
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==Overview==
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The Ku heterodimer (Ku70 and Ku80 subunits) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. The crystal structure of the human Ku heterodimer was determined both alone and bound to a 55-nucleotide DNA element at 2.7 and 2.5 A resolution, respectively. Ku70 and Ku80 share a common topology and form a dyad-symmetrical molecule with a preformed ring that encircles duplex DNA. The binding site can cradle two full turns of DNA while encircling only the central 3-4 base pairs (bp). Ku makes no contacts with DNA bases and few with the sugar-phosphate backbone, but it fits sterically to major and minor groove contours so as to position the DNA helix in a defined path through the protein ring. These features seem well designed to structurally support broken DNA ends and to bring the DNA helix into phase across the junction during end processing and ligation.
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(as it appears on PubMed at http://www.pubmed.gov), where 11493912 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11493912}}
==About this Structure==
==About this Structure==
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[[Category: Non-homologous end-joining]]
[[Category: Non-homologous end-joining]]
[[Category: Sap domain]]
[[Category: Sap domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:07:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:07:49 2008''

Revision as of 17:07, 1 July 2008

Image:1jeq.png

Template:STRUCTURE 1jeq

Crystal Structure of the Ku Heterodimer

Template:ABSTRACT PUBMED 11493912

About this Structure

1JEQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair., Walker JR, Corpina RA, Goldberg J, Nature. 2001 Aug 9;412(6847):607-14. PMID:11493912

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