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1hy9
From Proteopedia
(New page: 200px<br /> <applet load="1hy9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hy9" /> '''COCAINE AND AMPHETAMINE REGULATED TRANSCRIP...) |
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| - | [[Image:1hy9. | + | [[Image:1hy9.jpg|left|200px]]<br /><applet load="1hy9" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1hy9" size=" | + | |
caption="1hy9" /> | caption="1hy9" /> | ||
'''COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT'''<br /> | '''COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HY9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1HY9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: cysteine knot]] | [[Category: cysteine knot]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:58:39 2008'' |
Revision as of 13:58, 15 February 2008
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COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT
Overview
Cocaine and amphetamine regulated transcript (CART) peptide has been shown, to be an anorectic peptide that inhibits both normal and, starvation-induced feeding and completely blocks the feeding response, induced by neuropeptide Y and regulated by leptin in the hypothalamus. The, C-terminal part containing the three disulfide bridges CART(48-89) is the, biologically active part of the molecule affecting food intake. The, solution structure of the active part of CART has a fold equivalent to, other functionally distinct small proteins. CART consists mainly of turns, and loops spanned by a compact framework composed by a few small stretches, of antiparallel beta-sheet common to cystine knots.
About this Structure
1HY9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold., Ludvigsen S, Thim L, Blom AM, Wulff BS, Biochemistry. 2001 Aug 7;40(31):9082-8. PMID:11478874
Page seeded by OCA on Fri Feb 15 15:58:39 2008
