1jgg

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{{STRUCTURE_1jgg| PDB=1jgg | SCENE= }}
{{STRUCTURE_1jgg| PDB=1jgg | SCENE= }}
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'''Even-skipped Homeodomain Complexed to AT-rich DNA'''
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===Even-skipped Homeodomain Complexed to AT-rich DNA===
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==Overview==
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even-skipped is a homeobox gene important in controlling segment patterning in the embryonic fruit fly. Its homeobox encodes a DNA binding domain which binds with similar affinities to two DNA consensus sequences, one AT-rich, the other GC-rich. We describe a crystallographic analysis of the Even-skipped homeodomain complexed to an AT-rich oligonucleotide at 2.0 A resolution. The structure reveals a novel arrangement of two homeodomains bound to one 10 bp DNA sequence in a tandem fashion. This arrangement suggests a mechanism for the homeoproteins' regulatory specificity. In addition, the functionally important residue Gln50 is observed in multiple conformations making direct and water-mediated hydrogen bonds with the DNA bases.
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(as it appears on PubMed at http://www.pubmed.gov), where 8557047 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8557047}}
==About this Structure==
==About this Structure==
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[[Category: Homeodomain]]
[[Category: Homeodomain]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:12:28 2008''

Revision as of 17:12, 1 July 2008

Image:1jgg.png

Template:STRUCTURE 1jgg

Even-skipped Homeodomain Complexed to AT-rich DNA

Template:ABSTRACT PUBMED 8557047

About this Structure

1JGG is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity., Hirsch JA, Aggarwal AK, EMBO J. 1995 Dec 15;14(24):6280-91. PMID:8557047

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