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8bpp
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==crystal structure of N-ethylmaleimide reductase (nemA) from Escherichia coli== | |
| - | + | <StructureSection load='8bpp' size='340' side='right'caption='[[8bpp]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bpp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpp OCA], [https://pdbe.org/8bpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpp RCSB], [https://www.ebi.ac.uk/pdbsum/8bpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NEMA_ECOLI NEMA_ECOLI] Involved in the degradation of toxic compounds (PubMed:9013822, PubMed:15184158, PubMed:17504490, PubMed:23527133, PubMed:23506073, PubMed:23536188). Can use a variety of substrates, including the nitrate ester explosives glycerol trinitrate (GTN) and pentaerythritol tetranitrate (PETN), chromate and various electrophiles such as quinones (PubMed:15184158, PubMed:23527133, PubMed:23506073). Involved in resistance to hypochlorous acid (HOCl), which is the active component of household bleach and a powerful antimicrobial during the innate immune response (PubMed:23536188). Catalyzes the reduction of N-ethylmaleimide (NEM) to N-ethylsuccinimide (PubMed:9013822, PubMed:23506073). Together with NfsA and NfsB, can use the nitroaromatic explosive 2,4,6-trinitrotoluene (TNT) (PubMed:17504490).<ref>PMID:15184158</ref> <ref>PMID:17504490</ref> <ref>PMID:23506073</ref> <ref>PMID:23527133</ref> <ref>PMID:23536188</ref> <ref>PMID:9013822</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Erb T]] | ||
| + | [[Category: Pfister P]] | ||
| + | [[Category: Tinzl M]] | ||
Current revision
crystal structure of N-ethylmaleimide reductase (nemA) from Escherichia coli
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