1jhi

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[[Image:1jhi.gif|left|200px]]
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{{STRUCTURE_1jhi| PDB=1jhi | SCENE= }}
{{STRUCTURE_1jhi| PDB=1jhi | SCENE= }}
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'''Solution Structure of a Hedamycin-DNA complex'''
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===Solution Structure of a Hedamycin-DNA complex===
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==Overview==
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Hedamycin, a member of the pluramycin family of drugs, displays a range of biological responses including antitumor and antimicrobial activity. The mechanism of action is via direct interaction with DNA through intercalation between the bases of the oligonucleotide and alkylation of a guanine residue at 5'-PyG-3' sites. There appears to be some minor structural differences between two earlier studies on the interaction of hedamycin with 5'-PyG-3' sites. In this study, a high-resolution NMR analysis of the hedamycin:d(ACCGGT)2 complex was undertaken in order to investigate the effect of replacing the thymine with a guanine at the preferred 5'-CGT-3' site. The resultant structure was compared with earlier work, with particular emphasis placed on the drug conformation. The structure of the hedamycin:d(ACCGGT)2 complex has many features in common with the two previous NMR structures of hedamycin:DNA complexes but differed in the conformation and orientation of the N,N-dimethylvancosamine saccharide of hedamycin in one of these structures. The preferential binding of hedamycin to 5'-CG-3' over 5'-TG-3' binding sites is explained in terms of the orientation and location of the N,N-dimethylvancosamine saccharide in the minor groove.
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The line below this paragraph, {{ABSTRACT_PUBMED_11820806}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11820806 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11820806}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHI OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHI OCA].
==Reference==
==Reference==
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[[Category: Duplex dna]]
[[Category: Duplex dna]]
[[Category: Hedamycin]]
[[Category: Hedamycin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:13:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:15:15 2008''

Revision as of 17:15, 1 July 2008

Image:1jhi.png

Template:STRUCTURE 1jhi

Solution Structure of a Hedamycin-DNA complex

Template:ABSTRACT PUBMED 11820806

About this Structure

Full experimental information is available from OCA.

Reference

Structural investigation of the hedamycin:d(ACCGGT)2 complex by NMR and restrained molecular dynamics., Owen EA, Burley GA, Carver JA, Wickham G, Keniry MA, Biochem Biophys Res Commun. 2002 Feb 8;290(5):1602-8. PMID:11820806

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