1jhl

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{{STRUCTURE_1jhl| PDB=1jhl | SCENE= }}
{{STRUCTURE_1jhl| PDB=1jhl | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF A HETEROCLITIC ANTIGEN-ANTIBODY CROSS-REACTION COMPLEX'''
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===THREE-DIMENSIONAL STRUCTURE OF A HETEROCLITIC ANTIGEN-ANTIBODY CROSS-REACTION COMPLEX===
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==Overview==
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Although antibodies are highly specific, cross-reactions are frequently observed. To understand the molecular basis of this phenomenon, we studied the anti-hen egg lysozyme (HEL) monoclonal antibody (mAb) D11.15, which cross-reacts with several avian lysozymes, in some cases with a higher affinity (heteroclitic binding) than for HEL. We have determined the crystal structure of the Fv fragment of D11.15 complexed with pheasant egg lysozyme (PHL). In addition, we have determined the structure of PHL, Guinea fowl egg lysozyme, and Japanese quail egg lysozyme. Differences in the affinity of D11.15 for the lysozymes appear to result from sequence substitutions in these antigens at the interface with the antibody. More generally, cross-reactivity is seen to require a stereochemically permissive environment for the variant antigen residues at the antibody-antigen interface.
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{{ABSTRACT_PUBMED_8356074}}
==About this Structure==
==About this Structure==
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[[Category: Eisele, J L.]]
[[Category: Eisele, J L.]]
[[Category: Poljak, R J.]]
[[Category: Poljak, R J.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:15:28 2008''

Revision as of 17:15, 1 July 2008

Image:1jhl.png

Template:STRUCTURE 1jhl

THREE-DIMENSIONAL STRUCTURE OF A HETEROCLITIC ANTIGEN-ANTIBODY CROSS-REACTION COMPLEX

Template:ABSTRACT PUBMED 8356074

About this Structure

1JHL is a Protein complex structure of sequences from Mus musculus and Phasianus colchicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex., Chitarra V, Alzari PM, Bentley GA, Bhat TN, Eisele JL, Houdusse A, Lescar J, Souchon H, Poljak RJ, Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7711-5. PMID:8356074

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