1i27
From Proteopedia
(New page: 200px<br /> <applet load="1i27" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i27, resolution 1.02Å" /> '''CRYSTAL STRUCTURE O...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1i27.gif|left|200px]]<br /> | + | [[Image:1i27.gif|left|200px]]<br /><applet load="1i27" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1i27" size=" | + | |
caption="1i27, resolution 1.02Å" /> | caption="1i27, resolution 1.02Å" /> | ||
'''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)'''<br /> | '''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1I27 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1I27 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I27 OCA]. |
==Reference== | ==Reference== | ||
| Line 26: | Line 25: | ||
[[Category: winged-helix domain]] | [[Category: winged-helix domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:59:07 2008'' |
Revision as of 13:59, 15 February 2008
|
CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)
Overview
The x-ray structure of a C-terminal fragment of the RAP74 subunit of human, transcription factor (TF) IIF has been determined at 1.02-A resolution., The alpha/beta structure is strikingly similar to the globular domain of, linker histone H5 and the DNA-binding domain of hepatocyte nuclear factor, 3gamma (HNF-3gamma), making it a winged-helix protein. The surface, electrostatic properties of this compact domain differ significantly from, those of bona fide winged-helix transcription factors (HNF-3gamma and, RFX1) and from the winged-helix domains found within the RAP30 subunit of, TFIIF and the beta subunit of TFIIE. RAP74 has been shown to interact with, the TFIIF-associated C-terminal domain phosphatase FCP1, and a putative, phosphatase binding site has been identified within the RAP74 winged-helix, domain.
About this Structure
1I27 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the C-terminal domain of the RAP74 subunit of human transcription factor IIF., Kamada K, De Angelis J, Roeder RG, Burley SK, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3115-20. PMID:11248041
Page seeded by OCA on Fri Feb 15 15:59:07 2008
