This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1i27
From Proteopedia
(New page: 200px<br /> <applet load="1i27" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i27, resolution 1.02Å" /> '''CRYSTAL STRUCTURE O...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1i27.gif|left|200px]]<br /> | + | [[Image:1i27.gif|left|200px]]<br /><applet load="1i27" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1i27" size=" | + | |
caption="1i27, resolution 1.02Å" /> | caption="1i27, resolution 1.02Å" /> | ||
'''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)'''<br /> | '''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1I27 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1I27 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I27 OCA]. |
==Reference== | ==Reference== | ||
| Line 26: | Line 25: | ||
[[Category: winged-helix domain]] | [[Category: winged-helix domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:59:07 2008'' |
Revision as of 13:59, 15 February 2008
|
CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)
Overview
The x-ray structure of a C-terminal fragment of the RAP74 subunit of human, transcription factor (TF) IIF has been determined at 1.02-A resolution., The alpha/beta structure is strikingly similar to the globular domain of, linker histone H5 and the DNA-binding domain of hepatocyte nuclear factor, 3gamma (HNF-3gamma), making it a winged-helix protein. The surface, electrostatic properties of this compact domain differ significantly from, those of bona fide winged-helix transcription factors (HNF-3gamma and, RFX1) and from the winged-helix domains found within the RAP30 subunit of, TFIIF and the beta subunit of TFIIE. RAP74 has been shown to interact with, the TFIIF-associated C-terminal domain phosphatase FCP1, and a putative, phosphatase binding site has been identified within the RAP74 winged-helix, domain.
About this Structure
1I27 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the C-terminal domain of the RAP74 subunit of human transcription factor IIF., Kamada K, De Angelis J, Roeder RG, Burley SK, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3115-20. PMID:11248041
Page seeded by OCA on Fri Feb 15 15:59:07 2008
