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8a9q

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'''Unreleased structure'''
 
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The entry 8a9q is ON HOLD until Paper Publication
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==Computational design of stable mammalian serum albumins for bacterial expression==
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<StructureSection load='8a9q' size='340' side='right'caption='[[8a9q]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Khersonsky, O., Dym, O., Fleishman, J.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8a9q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A9Q FirstGlance]. <br>
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Description: Computational design of stable mammalian serum albumins for bacterial expression
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=RWF:R-WARFARIN'>RWF</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a9q OCA], [https://pdbe.org/8a9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a9q RCSB], [https://www.ebi.ac.uk/pdbsum/8a9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a9q ProSAT]</span></td></tr>
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[[Category: Fleishman, J.S]]
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</table>
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[[Category: Dym, O]]
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== Disease ==
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[[Category: Khersonsky, O]]
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Dym O]]
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[[Category: Fleishman JS]]
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[[Category: Khersonsky O]]

Revision as of 06:51, 10 May 2023

Computational design of stable mammalian serum albumins for bacterial expression

PDB ID 8a9q

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