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8hu2

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Current revision (10:05, 17 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8hu2 is ON HOLD until Paper Publication
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==Rattus Syntenin-1 PDZ domain with inhibitor==
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<StructureSection load='8hu2' size='340' side='right'caption='[[8hu2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Heo, Y., Lee, J., Yun, J.H., Lee, W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8hu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HU2 FirstGlance]. <br>
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Description: Rattus Syntenin-1 PDZ domain with inhibitor
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M8R:(2~{S})-2-(9~{H}-fluoren-9-ylmethoxycarbonylamino)-3-(4-oxidanylidene-5~{H}-pyrimidin-2-yl)propanoic+acid'>M8R</scene></td></tr>
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[[Category: Lee, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hu2 OCA], [https://pdbe.org/8hu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hu2 RCSB], [https://www.ebi.ac.uk/pdbsum/8hu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hu2 ProSAT]</span></td></tr>
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[[Category: Heo, Y]]
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</table>
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[[Category: Lee, W]]
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== Function ==
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[[Category: Yun, J.H]]
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[https://www.uniprot.org/uniprot/SDCB1_RAT SDCB1_RAT] Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.[UniProtKB:O00560]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Heo Y]]
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[[Category: Lee J]]
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[[Category: Lee W]]
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[[Category: Yun JH]]

Current revision

Rattus Syntenin-1 PDZ domain with inhibitor

PDB ID 8hu2

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