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1jlk

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{{STRUCTURE_1jlk| PDB=1jlk | SCENE= }}
{{STRUCTURE_1jlk| PDB=1jlk | SCENE= }}
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'''Crystal structure of the Mn(2+)-bound form of response regulator Rcp1'''
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===Crystal structure of the Mn(2+)-bound form of response regulator Rcp1===
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==Overview==
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The two-component signal transduction pathway widespread in prokaryotes, fungi, molds, and some plants involves an elaborate phosphorelay cascade. Rcp1 is the phosphate receiver module in a two-component system controlling the light response of cyanobacteria Synechocystis sp. via cyanobacterial phytochrome Cph1, which recognizes Rcp1 and transfers its phosphoryl group to an aspartate residue in response to light. Here we describe the crystal structure of Rcp1 refined to a crystallographic R-factor of 18.8% at a resolution of 1.9 A. The structure reveals a tightly associated homodimer with monomers comprised of doubly wound five-stranded parallel beta-sheets forming a single-domain protein homologous with the N-terminal activator domain of other response regulators (e.g., chemotaxis protein CheY). The three-dimensional structure of Rcp1 appears consistent with the conserved activation mechanism of phosphate receiver proteins, although in this case, the C-terminal half of its regulatory domain, which undergoes structural changes upon phosphorylation, contributes to the dimerization interface. The involvement of the residues undergoing phosphorylation-induced conformational changes at the dimeric interface suggests that dimerization of Rcp1 may be regulated by phosphorylation, which could affect the interaction of Rcp1 with downstream target molecules.
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(as it appears on PubMed at http://www.pubmed.gov), where 11847283 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11847283}}
==About this Structure==
==About this Structure==
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[[Category: Response regulator]]
[[Category: Response regulator]]
[[Category: Two-component system]]
[[Category: Two-component system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:22:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:26:00 2008''

Revision as of 17:26, 1 July 2008

Image:1jlk.png

Template:STRUCTURE 1jlk

Crystal structure of the Mn(2+)-bound form of response regulator Rcp1

Template:ABSTRACT PUBMED 11847283

About this Structure

1JLK is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of a cyanobacterial phytochrome response regulator., Im YJ, Rho SH, Park CM, Yang SS, Kang JG, Lee JY, Song PS, Eom SH, Protein Sci. 2002 Mar;11(3):614-24. PMID:11847283

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