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Inhibitory neurosteroids
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| - | <StructureSection load='5osb' size='340' side='right' caption='Mouse GLIC-GABAA receptor complex with corticosterone derivative, acetate and Cl- ion (PDB code [[5osb]]) | + | <StructureSection load='5osb' size='340' side='right' caption='Mouse GLIC-GABAA receptor complex with corticosterone derivative, acetate and Cl- ion (PDB code [[5osb]])'> |
These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects. | These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects. | ||
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