NKX2.5 Homeodomain

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Current revision (09:41, 16 January 2023) (edit) (undo)
 
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[[Image:Sequence2.png|thumb|right|upright=4|''Sequence alignment of NKX2.5 isoforms from multiple species. Red boxes indicate the continuous homeodomain region from residue 137-194.'']]
[[Image:Sequence2.png|thumb|right|upright=4|''Sequence alignment of NKX2.5 isoforms from multiple species. Red boxes indicate the continuous homeodomain region from residue 137-194.'']]
It is important to note that the residues involved in the recognition of the NKX2.5 motif are fully conserved across all isoforms. The cross-species similarities in NKX2.5 isozymes is of special importance in relation to research. For example, ''Danio rerio'' (Zebrafish) have been used as models to study heart development during gestation <ref> PMID: 10993952 </ref>, <ref> PMID: 28615160 </ref>. This is made possible by the fact that the ''Danio rerio'' and ''Homo sapien'' NKX2.5 share sequence similarities.
It is important to note that the residues involved in the recognition of the NKX2.5 motif are fully conserved across all isoforms. The cross-species similarities in NKX2.5 isozymes is of special importance in relation to research. For example, ''Danio rerio'' (Zebrafish) have been used as models to study heart development during gestation <ref> PMID: 10993952 </ref>, <ref> PMID: 28615160 </ref>. This is made possible by the fact that the ''Danio rerio'' and ''Homo sapien'' NKX2.5 share sequence similarities.
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=Homeobox protein Nkx-2.5 3D structures=
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[3rkq]] – hNkx-2.5 + DNA – human <br />
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[[6wc2]], [[6wc5]] – hNkx-2.5 + myocyte-specific enhancer factor 2B + DNA <br />
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[[4s0h]] – hNkx-2.5 + TBX5 + DNA <br />
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[[5flv]] – Nkx-2.5 + TBX5 + DNA - mouse<br />
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[[2l9r]] – hNkx-3.1 - NMR <br />
= References =
= References =
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

PDB ID 3rkq

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Proteopedia Page Contributors and Editors (what is this?)

William J Simard, Michal Harel

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