1jmm

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{{STRUCTURE_1jmm| PDB=1jmm | SCENE= }}
{{STRUCTURE_1jmm| PDB=1jmm | SCENE= }}
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'''Crystal structure of the V-region of Streptococcus mutans antigen I/II'''
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===Crystal structure of the V-region of Streptococcus mutans antigen I/II===
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==Overview==
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Antigens I/II are large multifunctional adhesins from oral viridans streptococci that exert immunomodulatory effects on human cells and play important roles in inflammatory disorders. Among them, Streptococcus mutans plays a major role in the initiation of dental caries. The structure of the V-region (SrV+, residues 464-840) of the antigen I/II of S. mutans has been determined using the multiwavelength anomalous diffraction phasing technique with seleno-methionine-substituted recombinant protein and subsequently refined at 2.4 A resolution. The crystal structure of SrV+ revealed a lectin-like fold that displays a putative preformed carbohydrate-binding site stabilized by a metal ion. Inhibition of this binding site may confer to humans a protection against dental caries and dissemination of the bacteria to extra-oral sites involved in life-threatening inflammatory diseases. This crystal structure constitutes a first step in understanding the structure-function relationship of antigens I/II and may help in delineating new preventive or therapeutic strategies against colonization of the host by oral streptococci.
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The line below this paragraph, {{ABSTRACT_PUBMED_12054777}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12054777 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12054777}}
==About this Structure==
==About this Structure==
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[[Category: Antigen i/ii]]
[[Category: Antigen i/ii]]
[[Category: V-region]]
[[Category: V-region]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:25:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:28:33 2008''

Revision as of 17:28, 1 July 2008

Image:1jmm.png

Template:STRUCTURE 1jmm

Crystal structure of the V-region of Streptococcus mutans antigen I/II

Template:ABSTRACT PUBMED 12054777

About this Structure

1JMM is a Single protein structure of sequence from Streptococcus mutans. Full crystallographic information is available from OCA.

Reference

Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site., Troffer-Charlier N, Ogier J, Moras D, Cavarelli J, J Mol Biol. 2002 Apr 19;318(1):179-88. PMID:12054777

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