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1jmt

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{{STRUCTURE_1jmt| PDB=1jmt | SCENE= }}
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'''X-ray Structure of a Core U2AF65/U2AF35 Heterodimer'''
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===X-ray Structure of a Core U2AF65/U2AF35 Heterodimer===
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==Overview==
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U2 auxiliary factor (U2AF) is an essential splicing factor that recognizes the 3' splice site and recruits the U2 snRNP to the branch point. The X-ray structure of the human core U2AF heterodimer, consisting of the U2AF35 central domain and a proline-rich region of U2AF65, has been determined at 2.2 A resolution. The structure reveals a novel protein-protein recognition strategy, in which an atypical RNA recognition motif (RRM) of U2AF35 and the U2AF65 polyproline segment interact via reciprocal "tongue-in-groove" tryptophan residues. Complementary biochemical experiments demonstrate that the core U2AF heterodimer binds RNA, and that the interacting tryptophan side chains are essential for U2AF dimerization. Atypical RRMs in other splicing factors may serve as protein-protein interaction motifs elsewhere during spliceosome assembly.
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(as it appears on PubMed at http://www.pubmed.gov), where 11551507 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11551507}}
==About this Structure==
==About this Structure==
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[[Category: Rna splicing]]
[[Category: Rna splicing]]
[[Category: Rrm]]
[[Category: Rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:25:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:28:57 2008''

Revision as of 17:28, 1 July 2008

Image:1jmt.png

Template:STRUCTURE 1jmt

X-ray Structure of a Core U2AF65/U2AF35 Heterodimer

Template:ABSTRACT PUBMED 11551507

About this Structure

1JMT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer., Kielkopf CL, Rodionova NA, Green MR, Burley SK, Cell. 2001 Sep 7;106(5):595-605. PMID:11551507

Page seeded by OCA on Tue Jul 1 20:28:57 2008

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