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1jn5

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{{STRUCTURE_1jn5| PDB=1jn5 | SCENE= }}
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'''Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain of TAP-p15 mRNA export factor'''
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===Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain of TAP-p15 mRNA export factor===
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==Overview==
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TAP-p15 heterodimers have been implicated in the export of mRNAs through nuclear pore complexes (NPCs). We report a structural analysis of the interaction domains of TAP and p15 in a ternary complex with a Phe-Gly (FG) repeat of an NPC component. The TAP-p15 heterodimer is structurally similar to the homodimeric transport factor NTF2, but unlike NTF2, it is incompatible with either homodimerization or Ran binding. The NTF2-like heterodimer functions as a single structural unit in recognizing an FG repeat at a hydrophobic pocket present only on TAP and not on p15. This FG binding site interacts synergistically with a second site at the C terminus of TAP to mediate mRNA transport through the pore. In general, our findings suggest that FG repeats bind with a similar conformation to different classes of transport factors.
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(as it appears on PubMed at http://www.pubmed.gov), where 11583626 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11583626}}
==About this Structure==
==About this Structure==
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[[Category: Ntf2-like domain]]
[[Category: Ntf2-like domain]]
[[Category: Nucleoporin]]
[[Category: Nucleoporin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:26:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:29:51 2008''

Revision as of 17:29, 1 July 2008

Image:1jn5.png

Template:STRUCTURE 1jn5

Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain of TAP-p15 mRNA export factor

Template:ABSTRACT PUBMED 11583626

About this Structure

1JN5 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor., Fribourg S, Braun IC, Izaurralde E, Conti E, Mol Cell. 2001 Sep;8(3):645-56. PMID:11583626

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