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1jnd

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[[Image:1jnd.gif|left|200px]]
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{{STRUCTURE_1jnd| PDB=1jnd | SCENE= }}
{{STRUCTURE_1jnd| PDB=1jnd | SCENE= }}
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'''Crystal structure of imaginal disc growth factor-2'''
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===Crystal structure of imaginal disc growth factor-2===
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==Overview==
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Imaginal disc growth factor-2 (IDGF-2) is a member of a recently described family of Drosophila melanogaster-soluble polypeptide growth factors that promote cell proliferation in imaginal discs. Although their precise mode of action has not been established, IDGFs cooperate with insulin in stimulating the growth of imaginal disc cells. We report the crystal structure of IDGF-2 at 1.3-A resolution. The structure shows the classical (betaalpha)(8) barrel-fold of family 18 glycosyl hydrolases, with an insertion of an alpha + beta domain similar to that of Serratia marcescens chitinases A and B. However, amino acid substitutions in the consensus catalytic sequence of chitinases give IDGF-2 a less negatively charged environment in its putative ligand-binding site and preclude the nucleophilic attack mechanism of chitin hydrolysis. Particularly important is the replacement of Glu by Gln at position 132, which has been shown to abolish enzymatic activity in chitinases. Nevertheless, a modest conservation of residues that participate in oligosaccharide recognition suggests that IDGF-2 could bind carbohydrates, assuming several conformational changes to open the partially occluded binding site. Thus, IDGFs may have evolved from chitinases to acquire new functions as growth factors, interacting with cell surface glycoproteins implicated in growth-promoting processes, such as the Drosophila insulin receptor.
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The line below this paragraph, {{ABSTRACT_PUBMED_11821393}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11821393 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11821393}}
==About this Structure==
==About this Structure==
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[[Category: Imaginal disc]]
[[Category: Imaginal disc]]
[[Category: Insulin receptor]]
[[Category: Insulin receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:26:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:30:20 2008''

Revision as of 17:30, 1 July 2008

Image:1jnd.png

Template:STRUCTURE 1jnd

Crystal structure of imaginal disc growth factor-2

Template:ABSTRACT PUBMED 11821393

About this Structure

1JND is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster., Varela PF, Llera AS, Mariuzza RA, Tormo J, J Biol Chem. 2002 Apr 12;277(15):13229-36. Epub 2002 Jan 30. PMID:11821393

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