1jnq

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{{STRUCTURE_1jnq| PDB=1jnq | SCENE= }}
{{STRUCTURE_1jnq| PDB=1jnq | SCENE= }}
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'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)'''
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===LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)===
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==Overview==
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Lipoxygenases (LOXs) are non-heme iron containing enzymes ubiquitous in nature and participating in the metabolism of the polyunsaturated fatty acids (PUFA). They are capable of combining their dioxygenase activity with its co-oxidative activity manifesting itself in biotransformation reactions catalyzed by LOXs for other than PUFA small molecules. LOXs involvement in inflammatory diseases and cancer have been well documented. Catechins are the natural flavonoids of known inhibitory activity toward dioxygenases with a potential to be utilized in disease prevention and treatment. This work presents results obtained from an X-ray analysis of (-)-epigallocatechin gallate (EGCG) interacting with soybean lipoxygenase-3. The 3D structure of the resulting complex reveals the inhibitor depicting (-)-epigallo-catechin that lacks galloyl moiety. The A-ring is near the iron co-factor, attached by the hydrogen bond to the C-terminus of the enzyme, and the B-ring hydroxyl groups participate in the hydrogen bonds and the van der Waals interactions formed by the surrounding amino acids and water molecules.
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(as it appears on PubMed at http://www.pubmed.gov), where 12964012 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12964012}}
==About this Structure==
==About this Structure==
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[[Category: Metalloprotein]]
[[Category: Metalloprotein]]
[[Category: Purple lipoxygenase]]
[[Category: Purple lipoxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:28:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:31:17 2008''

Revision as of 17:31, 1 July 2008

Image:1jnq.png

Template:STRUCTURE 1jnq

LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)

Template:ABSTRACT PUBMED 12964012

About this Structure

1JNQ is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead., Skrzypczak-Jankun E, Zhou K, Jankun J, Int J Mol Med. 2003 Oct;12(4):415-20. PMID:12964012

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