1jo2

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{{STRUCTURE_1jo2| PDB=1jo2 | SCENE= }}
{{STRUCTURE_1jo2| PDB=1jo2 | SCENE= }}
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'''Crystal Structure of the B-DNA Hexamer (CgATCG).Daunomycin Complex Containing a Ribose at the Intercalation Site'''
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===Crystal Structure of the B-DNA Hexamer (CgATCG).Daunomycin Complex Containing a Ribose at the Intercalation Site===
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==Overview==
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The crystal structure of a DNA/RNA chimera (dC)(rG)d(ATCG) complexed with the anticancer drug daunomycin has been determined at 1.5 A resolution with R(work) and R(free) of 19.7 and 23.3%, respectively, for 2767 reflections. The complex crystallizes in space group P4(1)2(1)2, with unit-cell parameters a = b = 28.05, c = 53.16 A, and contains one nucleic acid strand and one daunomycin molecule in the asymmetric unit. To our knowledge, this is the first crystal structure of a DNA/RNA chimera complexed with an intercalating drug. The DNA/RNA chimera adopts the B-form helical conformation, with the 2'-hydroxyl group in the major groove of the duplex, forming hydrogen bonds to N7 and the anionic phosphate oxygen of its 3'-side adenine. The present results indicate that the replacement by the ribose sugar in the DNA sequence does not change the geometry and intercalation pattern of daunomycin. A model of B-form RNA has been built based on the present structure. The model indicates that the interactions of the 2'-hydroxyl groups in the B-form duplex depend on their 3'-side nucleotides.
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(as it appears on PubMed at http://www.pubmed.gov), where 12876339 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12876339}}
==About this Structure==
==About this Structure==
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[[Category: Dna/rna chimer]]
[[Category: Dna/rna chimer]]
[[Category: Intercalation]]
[[Category: Intercalation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:29:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:32:24 2008''

Revision as of 17:32, 1 July 2008

Image:1jo2.png

Template:STRUCTURE 1jo2

Crystal Structure of the B-DNA Hexamer (CgATCG).Daunomycin Complex Containing a Ribose at the Intercalation Site

Template:ABSTRACT PUBMED 12876339

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a B-form DNA/RNA chimera (dC)(rG)d(ATCG) complexed with daunomycin at 1.5 A resolution., Shi K, Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1377-83. Epub 2003, Jul 23. PMID:12876339

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