LDL receptor

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Line 41: Line 41:
**[[5oy9]] – hLDLR LBD LB3 + glycoprotein G<br />
**[[5oy9]] – hLDLR LBD LB3 + glycoprotein G<br />
-
*hLDLR EGFP
+
*hLDLR EGFP domain 263-699
**[[1ijq]] – hLDLR YWTD-EGF<br />
**[[1ijq]] – hLDLR YWTD-EGF<br />
Line 54: Line 54:
**[[2w2n]], [[3gcw]] – hLDLR EGF1, EGF2 (mutant) + proprotein convertase subtilisin/kexin 9<br />
**[[2w2n]], [[3gcw]] – hLDLR EGF1, EGF2 (mutant) + proprotein convertase subtilisin/kexin 9<br />
-
*hLDLR cytoplasmic domain
+
*hLDLR cytoplasmic domain C terminal 817-832
**[[3so6]] – hLDLR C terminal + LDLR adaptor protein<br />
**[[3so6]] – hLDLR C terminal + LDLR adaptor protein<br />
-
*hLDLR lectin-like domain
+
*hLDLR lectin-like domain 136-273
 +
**[[1ypo]], [[1ypq]], [[1ypu]], [[7w5d]], [[7xmp]] – hLDLR<br />
**[[3vlg]] – hLDLR (mutant)<br />
**[[3vlg]] – hLDLR (mutant)<br />

Revision as of 05:57, 18 June 2023

Structure of human LDLR LBD and EGFP domains (magenta) complex with proprotein convertase subtilisin/kexin 9-CoA reductase (cyan and green) and Ca+2 ions (green) (PDB entry 3m0c)

Drag the structure with the mouse to rotate

3D structures of LDL receptor

Updated on 18-June-2023

References

  1. ↑ Goldstein JL, Brown MS. The LDL receptor. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):431-8. doi:, 10.1161/ATVBAHA.108.179564. PMID:19299327 doi:http://dx.doi.org/10.1161/ATVBAHA.108.179564
  2. ↑ Mak YT, Pang CP, Tomlinson B, Zhang J, Chan YS, Mak TW, Masarei JR. Mutations in the low-density lipoprotein receptor gene in Chinese familial hypercholesterolemia patients. Arterioscler Thromb Vasc Biol. 1998 Oct;18(10):1600-5. PMID:9763532

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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