8c7w

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m (Protected "8c7w" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8c7w is ON HOLD
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==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2304==
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<StructureSection load='8c7w' size='340' side='right'caption='[[8c7w]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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Authors: Cros, J., Williams, E.P., Sweeney, M.N., Smil, D., Gonzalez-Alvarez, H., Al-awar, R., Bullock, A.N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8c7w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C7W FirstGlance]. <br>
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Description: Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2304
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=U0C:6-methyl-9-piperazin-1-yl-4-(3,4,5-trimethoxyphenyl)-5,7-dihydropyrido[4,3-d][2]benzazepine'>U0C</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c7w OCA], [https://pdbe.org/8c7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c7w RCSB], [https://www.ebi.ac.uk/pdbsum/8c7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c7w ProSAT]</span></td></tr>
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[[Category: Williams, E.P]]
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</table>
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[[Category: Smil, D]]
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== Disease ==
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[[Category: Bullock, A.N]]
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] Fibrodysplasia ossificans progressiva. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:[https://omim.org/entry/135100 135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.<ref>PMID:16642017</ref> <ref>PMID:19085907</ref> <ref>PMID:19330033</ref>
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[[Category: Al-Awar, R]]
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== Function ==
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[[Category: Gonzalez-Alvarez, H]]
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
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[[Category: Cros, J]]
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== References ==
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[[Category: Sweeney, M.N]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Al-awar R]]
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[[Category: Bullock AN]]
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[[Category: Cros J]]
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[[Category: Gonzalez-Alvarez H]]
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[[Category: Smil D]]
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[[Category: Sweeney MN]]
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[[Category: Williams EP]]

Revision as of 06:46, 8 February 2023

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2304

PDB ID 8c7w

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