1joh

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{{STRUCTURE_1joh| PDB=1joh | SCENE= }}
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'''THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE'''
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===THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE===
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==Overview==
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BACKGROUND: Antiamoebin is a member of the peptaibol family of polypeptides and has a unique antibiotic activity: it acts as an antiamoebic agent, but does not effectively haemolyze erythrocytes even though it does exhibit membrane-modifying activity. RESULTS: The structure of antiamoebin I has been determined by X-ray crystallography at 1.4 A resolution. The molecule forms a helical structure, which, as a result of the presence of a number of proline and hydroxyproline residues, has a deep bend in the middle. Circular dichroism spectroscopy, single-channel conductance studies and fluorescence diffusion studies suggest a mode of ion transport that is entirely different from that of the other two members of the peptaibol family (alamethicin and zervamicin) whose structures and functions have been examined in detail. CONCLUSIONS: The structure of the polypeptide has been determined and a functional model for its mode of action in membranes is presented. Although under some conditions antiamoebin may form ion channels, unlike the closely related alamethicin and zervamicin polypeptides, its major membrane-modifying activity appears to be as an ion carrier.
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(as it appears on PubMed at http://www.pubmed.gov), where 9655831 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9655831}}
==About this Structure==
==About this Structure==
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[[Category: Peptaibol]]
[[Category: Peptaibol]]
[[Category: Peptide antibiotic]]
[[Category: Peptide antibiotic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:33:25 2008''

Revision as of 17:33, 1 July 2008

Image:1joh.png

Template:STRUCTURE 1joh

THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE

Template:ABSTRACT PUBMED 9655831

About this Structure

Full crystallographic information is available from OCA.

Reference

The structure and function of antiamoebin I, a proline-rich membrane-active polypeptide., Snook CF, Woolley GA, Oliva G, Pattabhi V, Wood SF, Blundell TL, Wallace BA, Structure. 1998 Jun 15;6(6):783-92. PMID:9655831

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