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1jou

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[[Image:1jou.jpg|left|200px]]
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{{STRUCTURE_1jou| PDB=1jou | SCENE= }}
{{STRUCTURE_1jou| PDB=1jou | SCENE= }}
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'''Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site'''
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===Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site===
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==Overview==
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Thrombin participates in its own positive and negative feedback loops, and its allosteric state helps determine the hemostatic balance. Here we present the 1.8 A crystallographic structure of S195A thrombin in two conformational states: active site occupied and active site free. The active site-occupied form shows how thrombin can accommodate substrates, such as protein C. The active site-free form is in a previously unobserved closed conformation of thrombin, which satisfies all the conditions of the so-called "slow" form. A mechanism of allostery is revealed, which relies on the concerted movement of the disulphide bond between Cys168 and 182 and aromatic residues Phe227, Trp215, and Trp60d. These residues constitute an allosteric switch, which is flipped directly through sodium binding, resulting in the fast form with an open active site.
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The line below this paragraph, {{ABSTRACT_PUBMED_12679024}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12679024 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12679024}}
==About this Structure==
==About this Structure==
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[[Category: Proteinase]]
[[Category: Proteinase]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:31:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:34:24 2008''

Revision as of 17:34, 1 July 2008

Image:1jou.png

Template:STRUCTURE 1jou

Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site

Template:ABSTRACT PUBMED 12679024

About this Structure

1JOU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form., Huntington JA, Esmon CT, Structure. 2003 Apr;11(4):469-79. PMID:12679024

Page seeded by OCA on Tue Jul 1 20:34:24 2008

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