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1jow

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[[Image:1jow.gif|left|200px]]
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{{STRUCTURE_1jow| PDB=1jow | SCENE= }}
{{STRUCTURE_1jow| PDB=1jow | SCENE= }}
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'''Crystal structure of a complex of human CDK6 and a viral cyclin'''
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===Crystal structure of a complex of human CDK6 and a viral cyclin===
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==Overview==
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Cyclin from herpesvirus saimiri (Vcyclin) preferentially forms complexes with cyclin-dependent kinase 6 (CDK6) from primate host cells. These complexes show higher kinase activity than host cell CDKs in complex with cellular cyclins and are resistant to cyclin-dependent inhibitory proteins (CDKIs). The crystal structure of human CDK6--Vcyclin in an active state was determined to 3.1 A resolution to better understand the structural basis of CDK6 activation by viral cyclins. The unphosphorylated CDK6 in complex with Vcyclin has many features characteristic of cyclinA-activated, phosphorylated CDK2. There are, however, differences in the conformation at the tip of the T-loop and its interactions with Vcyclin. Residues in the N-terminal extension of Vcyclin wrap around the tip of the CDK6 T-loop and form a short beta-sheet with the T-loop backbone. These interactions lead to a 20% larger buried surface in the CDK6--Vcyclin interface than in the CDK2--cyclinA complex and are probably largely responsible for the specificity of Vcyclin for CDK6 and resistance of the complex to inhibition by INK-type CDKIs.
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The line below this paragraph, {{ABSTRACT_PUBMED_11828325}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11828325 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11828325}}
==About this Structure==
==About this Structure==
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[[Category: Cdk-cyclin complex]]
[[Category: Cdk-cyclin complex]]
[[Category: Cyclin fold]]
[[Category: Cyclin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:31:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:34:30 2008''

Revision as of 17:34, 1 July 2008

Image:1jow.png

Template:STRUCTURE 1jow

Crystal structure of a complex of human CDK6 and a viral cyclin

Template:ABSTRACT PUBMED 11828325

About this Structure

1JOW is a Protein complex structure of sequences from Homo sapiens and Saimiriine herpesvirus 2. Full crystallographic information is available from OCA.

Reference

Structural basis for CDK6 activation by a virus-encoded cyclin., Schulze-Gahmen U, Kim SH, Nat Struct Biol. 2002 Mar;9(3):177-81. PMID:11828325

Page seeded by OCA on Tue Jul 1 20:34:30 2008

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