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1jpd

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{{STRUCTURE_1jpd| PDB=1jpd | SCENE= }}
{{STRUCTURE_1jpd| PDB=1jpd | SCENE= }}
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'''L-Ala-D/L-Glu Epimerase'''
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===L-Ala-D/L-Glu Epimerase===
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==Overview==
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The members of the enolase superfamily catalyze different overall reactions, yet share a partial reaction that involves Mg(2+)-assisted enolization of the substrate carboxylate anion. The fate of the resulting enolate intermediate is determined by the active site of each enzyme. Several members of this superfamily have been structurally characterized to permit an understanding of the evolutionary strategy for using a common structural motif to catalyze different overall reactions. In the preceding paper, two new members of the superfamily were identified that catalyze the epimerization of the glutamate residue in L-Ala-D/L-Glu. These enzymes belong to the muconate lactonizing enzyme subgroup of the enolase superfamily, and their sequences are only 31% identical. The structure of YcjG, the epimerase from Escherichia coli, was determined by MAD phasing using both the SeMet-labeled protein and a heavy atom derivative. The structure of YkfB, the epimerase from Bacillus subtilis, was determined by molecular replacement using the muconate lactonizing enzyme as a search model. In this paper, we report the three-dimensional structures of these enzymes and compare them to the structure of o-succinylbenzoate synthase, another member of the muconate lactonizing enzyme subgroup.
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(as it appears on PubMed at http://www.pubmed.gov), where 11747448 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11747448}}
==About this Structure==
==About this Structure==
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[[Category: Muconate lactonizing enzyme subgroup]]
[[Category: Muconate lactonizing enzyme subgroup]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:32:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:35:37 2008''

Revision as of 17:35, 1 July 2008

Image:1jpd.png

Template:STRUCTURE 1jpd

L-Ala-D/L-Glu Epimerase

Template:ABSTRACT PUBMED 11747448

About this Structure

1JPD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis., Gulick AM, Schmidt DM, Gerlt JA, Rayment I, Biochemistry. 2001 Dec 25;40(51):15716-24. PMID:11747448

Page seeded by OCA on Tue Jul 1 20:35:37 2008

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