4ocb

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ocb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ocb OCA], [https://pdbe.org/4ocb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ocb RCSB], [https://www.ebi.ac.uk/pdbsum/4ocb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ocb ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

A large number of Z-DNA hexamer duplex structures and a few oligomers of different lengths are available, but here the first crystal structure of the d(CGCGCGCGCGCG)2 dodecameric duplex is presented. Two synchrotron data sets were collected; one was used to solve the structure by the single-wavelength anomalous dispersion (SAD) approach based on the anomalous signal of P atoms, the other set, extending to an ultrahigh resolution of 0.75 A, served to refine the atomic model to an R factor of 12.2% and an R(free) of 13.4%. The structure consists of parallel duplexes arranged into practically infinitely long helices packed in a hexagonal fashion, analogous to all other known structures of Z-DNA oligomers. However, the dodecamer molecule shows a high level of flexibility, especially of the backbone phosphate groups, with six out of 11 phosphates modeled in double orientations corresponding to the two previously observed Z-DNA conformations: Z(I), with the phosphate groups inclined towards the inside of the helix, and Z(II), with the phosphate groups rotated towards the outside of the helix.

Phosphates in the Z-DNA dodecamer are flexible, but their P-SAD signal is sufficient for structure solution.,Luo Z, Dauter M, Dauter Z Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1790-800. doi:, 10.1107/S1399004714004684. Epub 2014 Jun 24. PMID:25004957<ref>PMID:25004957</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

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