1jpy

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[[Image:1jpy.gif|left|200px]]
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{{STRUCTURE_1jpy| PDB=1jpy | SCENE= }}
{{STRUCTURE_1jpy| PDB=1jpy | SCENE= }}
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'''Crystal structure of IL-17F'''
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===Crystal structure of IL-17F===
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==Overview==
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The proinflammatory cytokine interleukin 17 (IL-17) is the founding member of a family of secreted proteins that elicit potent cellular responses. We report a novel human IL-17 homolog, IL-17F, and show that it is expressed by activated T cells, can stimulate production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Unexpectedly, the crystal structure of IL-17F reveals that IL-17 family members adopt a monomer fold typical of cystine knot growth factors, despite lacking the disulfide responsible for defining the canonical "knot" structure. IL-17F dimerizes in a parallel manner like neurotrophins, and features an unusually large cavity on its surface. Remarkably, this cavity is located in precisely the same position where nerve growth factor binds its high affinity receptor, TrkA, suggesting further parallels between IL-17s and neurotrophins with respect to receptor recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_11574464}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11574464 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11574464}}
==About this Structure==
==About this Structure==
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[[Category: Dimer]]
[[Category: Dimer]]
[[Category: T-cell derived]]
[[Category: T-cell derived]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:35:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:37:04 2008''

Revision as of 17:37, 1 July 2008

Image:1jpy.png

Template:STRUCTURE 1jpy

Crystal structure of IL-17F

Template:ABSTRACT PUBMED 11574464

About this Structure

1JPY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding., Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA, EMBO J. 2001 Oct 1;20(19):5332-41. PMID:11574464

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