This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jqk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jqk.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1jqk.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jqk| PDB=1jqk | SCENE= }}
{{STRUCTURE_1jqk| PDB=1jqk | SCENE= }}
-
'''Crystal structure of carbon monoxide dehydrogenase from Rhodospirillum rubrum'''
+
===Crystal structure of carbon monoxide dehydrogenase from Rhodospirillum rubrum===
-
==Overview==
+
<!--
-
A crystal structure of the anaerobic Ni-Fe-S carbon monoxide dehydrogenase (CODH) from Rhodospirillum rubrum has been determined to 2.8-A resolution. The CODH family, for which the R. rubrum enzyme is the prototype, catalyzes the biological oxidation of CO at an unusual Ni-Fe-S cluster called the C-cluster. The Ni-Fe-S C-cluster contains a mononuclear site and a four-metal cubane. Surprisingly, anomalous dispersion data suggest that the mononuclear site contains Fe and not Ni, and the four-metal cubane has the form [NiFe(3)S(4)] and not [Fe(4)S(4)]. The mononuclear site and the four-metal cluster are bridged by means of Cys(531) and one of the sulfides of the cube. CODH is organized as a dimer with a previously unidentified [Fe(4)S(4)] cluster bridging the two subunits. Each monomer is comprised of three domains: a helical domain at the N terminus, an alpha/beta (Rossmann-like) domain in the middle, and an alpha/beta (Rossmann-like) domain at the C terminus. The helical domain contributes ligands to the bridging [Fe(4)S(4)] cluster and another [Fe(4)S(4)] cluster, the B-cluster, which is involved in electron transfer. The two Rossmann domains contribute ligands to the active site C-cluster. This x-ray structure provides insight into the mechanism of biological CO oxidation and has broader significance for the roles of Ni and Fe in biological systems.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11593006}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11593006 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11593006}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Sintchak, M D.]]
[[Category: Sintchak, M D.]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:39:34 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:39:03 2008''

Revision as of 17:39, 1 July 2008

Image:1jqk.png

Template:STRUCTURE 1jqk

Crystal structure of carbon monoxide dehydrogenase from Rhodospirillum rubrum

Template:ABSTRACT PUBMED 11593006

About this Structure

1JQK is a Single protein structure of sequence from Rhodospirillum rubrum. Full crystallographic information is available from OCA.

Reference

Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase., Drennan CL, Heo J, Sintchak MD, Schreiter E, Ludden PW, Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11973-8. Epub 2001 Oct 2. PMID:11593006

Page seeded by OCA on Tue Jul 1 20:39:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jqk"
Personal tools