1jqn

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{{STRUCTURE_1jqn| PDB=1jqn | SCENE= }}
{{STRUCTURE_1jqn| PDB=1jqn | SCENE= }}
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'''Crystal structure of E.coli phosphoenolpyruvate carboxylase in complex with Mn2+ and DCDP'''
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===Crystal structure of E.coli phosphoenolpyruvate carboxylase in complex with Mn2+ and DCDP===
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==Overview==
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Phosphoenolpyruvate carboxylase (PEPC) catalyzes the first step in the fixation of atmospheric CO(2) during C(4) photosynthesis. The crystal structure of C(4) form maize PEPC (ZmPEPC), the first structure of the plant PEPCs, has been determined at 3.0 A resolution. The structure includes a sulfate ion at the plausible binding site of an allosteric activator, glucose 6-phosphate. The crystal structure of E. coli PEPC (EcPEPC) complexed with Mn(2+), phosphoenolpyruvate analog (3,3-dichloro-2-dihydroxyphosphinoylmethyl-2-propenoate), and an allosteric inhibitor, aspartate, has also been determined at 2.35 A resolution. Dynamic movements were found in the ZmPEPC structure, compared with the EcPEPC structure, around two loops near the active site. On the basis of these molecular structures, the mechanisms for the carboxylation reaction and for the allosteric regulation of PEPC are proposed.
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The line below this paragraph, {{ABSTRACT_PUBMED_12467579}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12467579 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12467579}}
==About this Structure==
==About this Structure==
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[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Mn2+ and dcdp complex]]
[[Category: Mn2+ and dcdp complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:40:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:39:24 2008''

Revision as of 17:39, 1 July 2008

Image:1jqn.png

Template:STRUCTURE 1jqn

Crystal structure of E.coli phosphoenolpyruvate carboxylase in complex with Mn2+ and DCDP

Template:ABSTRACT PUBMED 12467579

About this Structure

1JQN is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structures of C4 form maize and quaternary complex of E. coli phosphoenolpyruvate carboxylases., Matsumura H, Xie Y, Shirakata S, Inoue T, Yoshinaga T, Ueno Y, Izui K, Kai Y, Structure. 2002 Dec;10(12):1721-30. PMID:12467579

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