1jr1

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{{STRUCTURE_1jr1| PDB=1jr1 | SCENE= }}
{{STRUCTURE_1jr1| PDB=1jr1 | SCENE= }}
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'''Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid'''
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===Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid===
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==Overview==
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The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication. MPA is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug recently approved for the treatment of allograft rejection. IMPDH comprises two domains: a core domain, which is an alpha/beta barrel and contains the active site, and a flanking domain. The complex, in combination with mutagenesis and kinetic data, provides a structural basis for understanding the mechanism of IMPDH activity and indicates that MPA inhibits IMPDH by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule.
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(as it appears on PubMed at http://www.pubmed.gov), where 8681386 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8681386}}
==About this Structure==
==About this Structure==
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[[Category: Mpa]]
[[Category: Mpa]]
[[Category: Mycophenolic acid]]
[[Category: Mycophenolic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:40:22 2008''

Revision as of 17:40, 1 July 2008

Image:1jr1.png

Template:STRUCTURE 1jr1

Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid

Template:ABSTRACT PUBMED 8681386

About this Structure

1JR1 is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid., Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP, Cell. 1996 Jun 14;85(6):921-30. PMID:8681386

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