1js3

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{{STRUCTURE_1js3| PDB=1js3 | SCENE= }}
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'''Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa'''
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===Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa===
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==Overview==
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DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. DDC has been implicated in a number of clinic disorders, including Parkinson's disease and hypertension. Peripheral inhibitors of DDC are currently used to treat these diseases. We present the crystal structures of ligand-free DDC and its complex with the anti-Parkinson drug carbiDOPA. The inhibitor is bound to the enzyme by forming a hydrazone linkage with the cofactor, and its catechol ring is deeply buried in the active site cleft. The structures provide the molecular basis for the development of new inhibitors of DDC with better pharmacological characteristics.
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(as it appears on PubMed at http://www.pubmed.gov), where 11685243 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11685243}}
==About this Structure==
==About this Structure==
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[[Category: Parkinson's disease]]
[[Category: Parkinson's disease]]
[[Category: Vitamin b6]]
[[Category: Vitamin b6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:48:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:43:17 2008''

Revision as of 17:43, 1 July 2008

Image:1js3.png


PDB ID 1js3

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1js3, resolution 2.25Å ()
Ligands: , ,
Activity: Aromatic-L-amino-acid decarboxylase, with EC number 4.1.1.28
Related: 1js6
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa

Template:ABSTRACT PUBMED 11685243

About this Structure

1JS3 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase., Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN, Nat Struct Biol. 2001 Nov;8(11):963-7. PMID:11685243

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