This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1js8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1js8.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1js8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1js8| PDB=1js8 | SCENE= }}
{{STRUCTURE_1js8| PDB=1js8 | SCENE= }}
-
'''Structure of a Functional Unit from Octopus Hemocyanin'''
+
===Structure of a Functional Unit from Octopus Hemocyanin===
-
==Overview==
+
<!--
-
Hemocyanins are giant oxygen transport proteins found in many arthropods and molluscs. Freely dissolved in the hemolymph, they are multisubunit proteins that contain many copies of the active site, a copper atom pair that reversibly binds oxygen. Octopus hemocyanin is composed of ten subunits, each of which contain seven oxygen-binding "functional units". The carboxyl-terminal 47 kDa functional unit, Odg, is a proteolytic isolate that binds oxygen reversibly while exhibiting slight Bohr and magnesium ion effects. In this work we present the X-ray structure determination and analysis of Odg at 2.3 A resolution. Odg has two structural domains: a largely alpha-helical copper binding domain, and a five-stranded anti-parallel beta-sandwich with the jelly roll topology found in many viruses. Six histidine residues ligate the copper atoms, one of which is involved in a thioether bridge. The results show that the hemocyanin from the mollusc and that from the arthropod have distinct tertiary folds in addition to the long recognized differences in their quaternary structures. Nonetheless, a comparison of Octopus and horseshoe crab hemocyanin reveals a similar active site, in a striking example of perhaps both convergent and divergent evolution.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9614947}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9614947 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9614947}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Oxygen-transport]]
[[Category: Oxygen-transport]]
[[Category: Thioether bond]]
[[Category: Thioether bond]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:49:39 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:43:39 2008''

Revision as of 17:43, 1 July 2008

Image:1js8.png

Template:STRUCTURE 1js8

Structure of a Functional Unit from Octopus Hemocyanin

Template:ABSTRACT PUBMED 9614947

About this Structure

1JS8 is a Single protein structure of sequence from Octopus dofleini. Full crystallographic information is available from OCA.

Reference

Crystal structure of a functional unit from Octopus hemocyanin., Cuff ME, Miller KI, van Holde KE, Hendrickson WA, J Mol Biol. 1998 May 15;278(4):855-70. PMID:9614947

Page seeded by OCA on Tue Jul 1 20:43:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1js8"
Personal tools