2jf0
From Proteopedia
(New page: 200px<br /> <applet load="2jf0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jf0, resolution 2.50Å" /> '''MUS MUSCULUS ACETYL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2JF0 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with P6G and HBP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JF0 OCA]]. | + | 2JF0 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with P6G and HBP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JF0 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: tabun]] | [[Category: tabun]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:40:51 2007'' |
Revision as of 09:36, 30 October 2007
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MUS MUSCULUS ACETYLCHOLINESTERASE IN COMPLEX WITH TABUN AND ORTHO-7
Overview
Organophosphorus compound-based nerve agents inhibit the essential enzyme, acetylcholinesterase (AChE) causing acute toxicity and death. Clinical, treatment of nerve-agent poisoning is to use oxime-based antidotes to, reactivate the inhibited AChE. However, the nerve agent tabun is resistant, to oximes. To design improved oximes, crystal structures of a, tabun-conjugated AChE in complex with different oximes are needed to guide, the structural modifications of known antidotes. However, this type of, structure is extremely challenging to obtain because both deamidation of, the tabun conjugate and reactivation of AChE occur during crystallographic, experiments. Here we report, for the first time, the crystal structures of, Ortho-7 and HLo-7 in complex with AChE that is conjugated to an ... [(full description)]
About this Structure
2JF0 is a [Single protein] structure of sequence from [Mus musculus] with P6G and HBP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Novel Nerve-Agent Antidote Design Based on Crystallographic and Mass Spectrometric Analyses of Tabun-Conjugated Acetylcholinesterase in Complex with Antidotes., Ekstrom FJ, Astot C, Pang YP, Clin Pharmacol Ther. 2007 Apr 18;. PMID:17443135
Page seeded by OCA on Tue Oct 30 11:40:51 2007
Categories: Mus musculus | Single protein | Astot, C. | Ekstrom, F. | Pang, Y.P. | HBP | P6G | Acetylcholinesterase | Alternative splicing | Glycoprotein | Hydrolase | Membrane | Mouse | Neurotransmitter degradation | Ortho-7 | Oxime | Serine esterase | Synapse | Tabun
