1jsm

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[[Image:1jsm.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1jsm| PDB=1jsm | SCENE= }}
{{STRUCTURE_1jsm| PDB=1jsm | SCENE= }}
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'''STRUCTURE OF H5 AVIAN HAEMAGGLUTININ'''
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===STRUCTURE OF H5 AVIAN HAEMAGGLUTININ===
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==Overview==
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There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 swine viruses closely related to the viruses isolated from humans in Hong Kong. We have compared them with known structures of the H3 HA from the virus that caused the 1968 H3 pandemic and of the HA--esterase--fusion (HEF) glycoprotein from an influenza C virus. Structure and sequence comparisons suggest that HA subtypes may have originated by diversification of properties that affected the metastability of HAs required for their membrane fusion activities in viral infection.
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The line below this paragraph, {{ABSTRACT_PUBMED_11867515}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11867515 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11867515}}
==About this Structure==
==About this Structure==
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[[Category: Influenza]]
[[Category: Influenza]]
[[Category: Receptor complex]]
[[Category: Receptor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:51:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:44:31 2008''

Revision as of 17:44, 1 July 2008

Image:1jsm.png

Template:STRUCTURE 1jsm

STRUCTURE OF H5 AVIAN HAEMAGGLUTININ

Template:ABSTRACT PUBMED 11867515

About this Structure

Full crystallographic information is available from OCA.

Reference

H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, EMBO J. 2002 Mar 1;21(5):865-75. PMID:11867515

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