1jtd

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{{STRUCTURE_1jtd| PDB=1jtd | SCENE= }}
{{STRUCTURE_1jtd| PDB=1jtd | SCENE= }}
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'''Crystal structure of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase'''
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===Crystal structure of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase===
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==Overview==
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The structure of the 28 kDa beta-lactamase inhibitor protein-II (BLIP-II) in complex with the TEM-1 beta-lactamase has been determined to 2.3 A resolution. BLIP-II is a secreted protein produced by the soil bacterium Streptomyces exfoliatus SMF19 and is able to bind and inhibit TEM-1 with subnanomolar affinity. BLIP-II is a seven-bladed beta-propeller with a unique blade motif consisting of only three antiparallel beta-strands. The overall fold is highly similar to the core structure of the human regulator of chromosome condensation (RCC1). Although BLIP-II does not share the same fold with BLIP, the first beta-lactamase inhibitor protein for which structural data was available, a comparison of the two complexes reveals a number of similarities and provides further insights into key components of the TEM-1-BLIP and TEM-1-BLIP-II interfaces. Our preliminary results from gene knock-out studies and scanning electron microscopy also reveal a critical role of BLIP-II in sporulation.
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The line below this paragraph, {{ABSTRACT_PUBMED_11573088}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11573088 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11573088}}
==About this Structure==
==About this Structure==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Tem-1 beta-lactamase]]
[[Category: Tem-1 beta-lactamase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:53:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:46:19 2008''

Revision as of 17:46, 1 July 2008

Image:1jtd.png

Template:STRUCTURE 1jtd

Crystal structure of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase

Template:ABSTRACT PUBMED 11573088

About this Structure

1JTD is a Protein complex structure of sequences from Escherichia coli and Streptomyces exfoliatus. Full crystallographic information is available from OCA.

Reference

Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase., Lim D, Park HU, De Castro L, Kang SG, Lee HS, Jensen S, Lee KJ, Strynadka NC, Nat Struct Biol. 2001 Oct;8(10):848-52. PMID:11573088

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