8fkm

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Current revision (11:15, 14 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8fkm is ON HOLD until Paper Publication
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==Human Atg3 with deletions of residues 1 to 25 and 90 to 190==
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<StructureSection load='8fkm' size='340' side='right'caption='[[8fkm]]' scene=''>
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Authors: Ye, Y.S., Tian, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8fkm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FKM FirstGlance]. <br>
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Description: Human Atg3 with deletions of residues 90 to 190 and H240Y, V241A, P263G, and H266L mutations
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fkm OCA], [https://pdbe.org/8fkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fkm RCSB], [https://www.ebi.ac.uk/pdbsum/8fkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fkm ProSAT]</span></td></tr>
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[[Category: Ye, Y.S]]
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</table>
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[[Category: Tian, F]]
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== Function ==
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[https://www.uniprot.org/uniprot/ATG3_HUMAN ATG3_HUMAN] E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.<ref>PMID:11825910</ref> <ref>PMID:12207896</ref> <ref>PMID:12890687</ref> <ref>PMID:16704426</ref> <ref>PMID:20723759</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Tian F]]
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[[Category: Ye YS]]

Current revision

Human Atg3 with deletions of residues 1 to 25 and 90 to 190

PDB ID 8fkm

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