8i40

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Current revision (11:42, 1 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8i40 is ON HOLD until Paper Publication
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==Crystal structure of ASCT from Trypanosoma brucei in complex with CoA.==
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<StructureSection load='8i40' size='340' side='right'caption='[[8i40]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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Authors: Mochizuki, K., Inaoka, D.K., Fukuda, K., Kurasawa, H., Iyoda, K., Nakai, U., Harada, S., Balogun, E.O., Mazet, M., Millerioux, Y., Bringaud, F., Boshart, M., Hirayama, K., Kita, K., Shiba, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8i40]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I40 FirstGlance]. <br>
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Description: Crystal structure of ASCT from Trypanosoma brucei in complex with CoA.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
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[[Category: Hirayama, K]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i40 OCA], [https://pdbe.org/8i40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i40 RCSB], [https://www.ebi.ac.uk/pdbsum/8i40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i40 ProSAT]</span></td></tr>
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[[Category: Mazet, M]]
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</table>
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[[Category: Shiba, T]]
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== Function ==
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[[Category: Inaoka, D.K]]
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[https://www.uniprot.org/uniprot/Q386P1_TRYB2 Q386P1_TRYB2] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.[PIRNR:PIRNR000858]
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[[Category: Kita, K]]
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__TOC__
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[[Category: Millerioux, Y]]
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</StructureSection>
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[[Category: Balogun, E.O]]
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[[Category: Large Structures]]
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[[Category: Nakai, U]]
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[[Category: Trypanosoma brucei brucei TREU927]]
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[[Category: Kurasawa, H]]
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[[Category: Balogun EO]]
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[[Category: Iyoda, K]]
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[[Category: Boshart M]]
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[[Category: Fukuda, K]]
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[[Category: Bringaud F]]
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[[Category: Harada, S]]
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[[Category: Fukuda K]]
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[[Category: Bringaud, F]]
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[[Category: Harada S]]
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[[Category: Mochizuki, K]]
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[[Category: Hirayama K]]
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[[Category: Boshart, M]]
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[[Category: Inaoka DK]]
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[[Category: Iyoda K]]
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[[Category: Kita K]]
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[[Category: Kurasawa H]]
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[[Category: Mazet M]]
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[[Category: Millerioux Y]]
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[[Category: Mochizuki K]]
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[[Category: Nakai U]]
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[[Category: Shiba T]]

Current revision

Crystal structure of ASCT from Trypanosoma brucei in complex with CoA.

PDB ID 8i40

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OCA

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