1jun

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{{STRUCTURE_1jun| PDB=1jun | SCENE= }}
{{STRUCTURE_1jun| PDB=1jun | SCENE= }}
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'''NMR STUDY OF C-JUN HOMODIMER'''
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===NMR STUDY OF C-JUN HOMODIMER===
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==Overview==
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The solution structure of the c-Jun leucine zipper domain has been determined to high resolution using a new calculation protocol designed to handle highly ambiguous sets of interproton distance restraints. The domain comprises a coiled coil of parallel alpha-helices in which most of the hydrophobic residues are buried at the highly symmetrical dimer interface; this interface extends over 10 helical turns and is the most elongated protein domain solved to date using NMR methods. The backbone fold is very similar to that seen in crystal structures of the GCN4 and Jun-Fos leucine zippers; however, in contrast with these crystal structures, the Jun leucine zipper dimer appears to be devoid of favorable intermolecular electrostatic interactions. A polar asparagine residue, located at the dimer interface, forms the sole point of asymmetry in the structure; furthermore, the side chain of this residue is disordered due to motional averaging. This residue, which is highly conserved in the leucine zipper family of transcription factors, provides a destabilizing influence that is likely to facilitate the rapid exchange of zipper strands in vivo.
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{{ABSTRACT_PUBMED_8662824}}
==About this Structure==
==About this Structure==
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1JUN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA].
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1JUN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA].
==Reference==
==Reference==
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[[Category: Transcription activation]]
[[Category: Transcription activation]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:55:07 2008''

Revision as of 17:55, 1 July 2008

Image:1jun.png

Template:STRUCTURE 1jun

NMR STUDY OF C-JUN HOMODIMER

Template:ABSTRACT PUBMED 8662824

About this Structure

1JUN is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer., Junius FK, O'Donoghue SI, Nilges M, Weiss AS, King GF, J Biol Chem. 1996 Jun 7;271(23):13663-7. PMID:8662824

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