1jvr

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{{STRUCTURE_1jvr| PDB=1jvr | SCENE= }}
{{STRUCTURE_1jvr| PDB=1jvr | SCENE= }}
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'''STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES'''
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===STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES===
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==Overview==
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The matrix protein performs similar roles in all retroviruses, initially directing membrane localization of the assembling viral particle and subsequently forming a stable structural shell associated with the inner surface of the mature viral membrane. Although conserved structural elements are likely to perform these functions in all retroviral matrix proteins, invariant motifs are not evident at the primary sequence level and three-dimensional structures have been available for only the primate lentiviral matrix proteins. We have therefore used NMR spectroscopy to determine the structure of the matrix protein from human T-cell leukemia virus type II (HTLV-II), a member of the human oncovirus subclass of retroviruses. A total of 577 distance restraints were used to build 20 refined models that superimpose with an rmsd of 0.71 A for the backbone atoms of the structured regions. The globular HTLV-II matrix structure is composed of four alpha-helices and a 3(10) helix. Exposed basic residues near the C terminus of helix II form a putative membrane binding surface which could act in concert with the N-terminal myristoyl group to anchor the protein on the viral membrane surface. Clear structural similarities between the HTLV-II and HIV-1 matrix proteins suggest that the topology and exposed cationic membrane binding surface are likely to be conserved features of retroviral matrix proteins.
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{{ABSTRACT_PUBMED_9000634}}
==About this Structure==
==About this Structure==
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1JVR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_t-cell_leukemia_virus_type_ii Human t-cell leukemia virus type ii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA].
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1JVR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_t-cell_leukemia_virus_type_ii Human t-cell leukemia virus type ii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA].
==Reference==
==Reference==
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[[Category: P17]]
[[Category: P17]]
[[Category: Retroviral matrix protein]]
[[Category: Retroviral matrix protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:59:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:01:18 2008''

Revision as of 18:01, 1 July 2008

Image:1jvr.png

Template:STRUCTURE 1jvr

STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9000634

About this Structure

1JVR is a Single protein structure of sequence from Human t-cell leukemia virus type ii. Full experimental information is available from OCA.

Reference

Three-dimensional structure of the HTLV-II matrix protein and comparative analysis of matrix proteins from the different classes of pathogenic human retroviruses., Christensen AM, Massiah MA, Turner BG, Sundquist WI, Summers MF, J Mol Biol. 1996 Dec 20;264(5):1117-31. PMID:9000634

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